Record Display for the EPA National Library Catalog


Main Title Investigation of selected potential environmental contaminants, Acrylonitrile : final report /
Author Miller, Lynne M. ; Villaume., Jon E.
Other Authors
Author Title of a Work
Villaume, Jon E.
Hilgard, Patricia
Letkiewicz, Frank J.
CORP Author Franklin Inst. Research Labs., Philadelphia, Pa.;Environmental Protection Agency, Washington, D.C. Office of Toxic Substances.
Publisher United States Environmental Protection Agency ; Reproduced [and distributed] by National Technical Information Service,
Year Published 1978
Report Number EPA/560-2-78-003; FIRL-80G-C4807-01; FIRL-F-C4807-01; EPA-68-01-3893
Stock Number PB-285 881
OCLC Number 04913825
Subjects Acrylonitrile. ; Pollutants.
Additional Subjects Acrylonitriles ; Industrial medicine ; Toxicology ; Chemical industry ; Toxicity ; Nitriles ; Reviews ; Assessments ; Exposure ; Production ; Standards ; States(United States) ; Foreign countries ; Recommendations ; Utilization ; Regulations ; Carcinogens ; Malignant neoplasms ; Mutations ; Congenital abnormalities ; Laboratory animals ; Experimental data ; Physiological effects ; Humans ; Carcinogenesis ; Literature surveys ; Biological effects ; Occupational safety and health ; Air pollution effects(Humans) ; Air pollution effects(Animals)
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA 560-2-78-003 Headquarters Library/Washington,DC 12/07/2015
EJED  EPA 560-2-78-003 OCSPP Chemical Library/Washington,DC 03/14/2016
NTIS  PB-285 881 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation xii, 234 pages ; 28 cm
The report is a survey and summary of the literature on acrylonitrile. Major aspects of its biological effects, environmental exposure, chemistry, production and use, and regulations are reviewed and assessed. Acrylonitrile is used in a wide variety of plastics, fibers, and elastomers. About 1.5 billion pounds of acrylonitrile are produced annually by the reaction of propylene, air, and ammonia. Low levels of acrylonitrile enter the environment during production, storage, end-product manufacture and end-use, although extensive monitoring data are not available. Recent evidence shows acrylonitrile to be carcinogenic in animals and possibly carcinogenic in humans. It resulted in birth defects when fed to pregnant rats and caused mutations in some type of bacteria. Short-term exposure to humans causes headache, mucus membrane irritation, dizziness, vomiting and incoordination. Several fatalities have resulted from fumigant use. Direct skin contact produces blisters resembling second-degree burns. In laboratory mammals, signs of acrylonitrile intoxication include altered breathing, incoordination, weakness, convulsions, and coma.
"EPA/560-2-78-003." "May 1978." PB 285 881. Project Officer : Frank J. Letkiewicz Includes bibliographical references (pages 213-230). Final report ; Sponsored by Office of Toxic Substances, U.S. Environmental Protection Agency ;