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Main Title Study of the chemical and behavioral toxicology of substitute chemicals in microtine rodents /
Author Cholakis, J. M., ; Wond, Laurence C. K. ; Lee, Cheng-Chun
Other Authors
Author Title of a Work
Wong, L. C. K.,
Lee, Cheng-Chun,
CORP Author Midwest Research Institute (Kansas City, Mo.); Pacific Environmental Research Laboratory.; Midwest Research Inst., Kansas City, MO.; Corvallis Environmental Research Lab., OR.
Publisher U.S. Corvallis Environmental Research Laboratory,
Year Published 1978
Report Number EPA-600/3-78-082; MRI 4298-B; EPA-68-01-4195; PB288416
Stock Number PB-288 416
OCLC Number 04506711
Subjects Pesticides and wildlife ; Pesticides--Toxicology ; Microtus
Additional Subjects Pesticides and wildlife ; Pesticides--Toxicology ; Microtus ; Insecticides ; Herbicides ; Behavior ; Rodents ; Lethal dosage ; Diets ; Ingestion(Biology) ; Laboratory animals ; Experimental data ; Dose rate ; Sensitivity ; Females ; Males ; Concentration(Composition) ; Chlorine organic compounds ; Dieldrin ; Toxicity ; Tables(Data) ; Microtus ochrogaster ; Animal models ; Toxic substances ; Voles ; D 24 herbicide ; Acetic acid/dichlorophenoxy ; Phosphorothioic acid/0-0-(dimethyl-ester)-0-(nitrophenylester) ; Benzene/nitro-pentachloro ; Acetic acid/trichlorophenoxy ; T2-4-5 herbicide ; Propanil ; Propionanilide/dichloro ; Simazine ; Triazine/bis(ethylamino)-chloro ; Environmental chemical substitutes ; Microtus canicaudus ; Microtus pennsylvanicus ; Microtus montanus ; Dimethanonaphthalenes ; PCNB fungicide ; Methyl parathion ; Benzene/hexachloro ; Toluidine/trifluoro-dinitro-N-N-dipropyl
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJED  EPA-600/3-78-082 OCSPP Chemical Library/Washington,DC 03/13/1999
EKBD  EPA-600/3-78-082 Research Triangle Park Library/RTP, NC 07/18/2003
ELBD ARCHIVE EPA 600/3-78-082 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ESAD  EPA 600-3-78-082 Region 10 Library/Seattle,WA 08/22/2017
NTIS  PB-288 416 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation vi, 54 pages ; 28 cm.
Acute oral LD50 and 30-day dietary subacute LC50 studies of 10 selected pesticides were evaluated in microtine rodents. As a means to developing new animal model systems, four species of microtine rodents including Microtus ochrogaster (MO), Microtus canicaudus (MC), Microtus pennsylvanicus (MP) and Microtus montanus (MM) voles were used. The acute LD50 (median lethal dose in mg/kg) in all four species and the subacute LC50 (median lethal concentration in ppm) in MO and MC voles were computed using probit analysis. The data from both the acute and the 30-day subacute studies revealed that MC voles were approximately twice as sensitive to these pesticides as MO voles. Based on the acute studies, the overall order of pesticide toxicity was as follows: parathion > methyl parathion > dieldrin > 2,4-D > 2,4,5-T > simazine propanil = PCNB = HCB = trifluralin. The general order of species sensitivity was as follows: MC> MP> MO>MM. No apparent sex differences were observed in MP, MO or MM voles. In MC voles, the female appeared to be two- to three-fold more sensitive to methyl parathion than the male. Based on the 30-day subacute LC50 studies, the overall order of pesticide toxicity is as follows: dieldrin> parathion> methyl parathion> HCB> 2,4,5-T> PCNS> propanil. Based on LD50 values the laboratory rodents appear to be more susceptible to 2,4-D, dieldrin, methyl parathion, parathion, propanil, and 2,4,5-T, equally susceptible to HCB, PCNB, and trifluralin, and less susceptible to simazine than the MC voles.
Midwest Research Institute. Prepared for the U.S. Environmental Protection Agency, Office of Research and Development, Corvallis Environmental Research Laboratory, under Contract no. 68-01-4915. Issued Aug. 1978. Includes bibliographical references (pages 19-20).