| Main Title |
Statistical approach to predicting chronic toxicity of chemicals to fishes from acute toxicity test data / |
| Author |
Mayer, Foster L. ;
Krause, G. F. ;
Ellersieck, M. R. ;
Lee, G.
|
| Other Authors |
|
| CORP Author |
Environmental Research Lab., Gulf Breeze, FL. ;Missouri Agricultural Experiment Station, Columbia. |
| Publisher |
U.S. Environmental Protection Agency, Environmental Research Laboratory, Office of Research & Development, |
| Year Published |
1992 |
| Report Number |
EPA/600/R-92/091; EPA/SW/DK-92/047A |
| Stock Number |
PB92-169655 |
| OCLC Number |
45877986 |
| Subjects |
Acute toxicity testing ;
Fishes--Effect of chemicals on
|
| Additional Subjects |
Water pollution effects ;
Fishes ;
Toxicity ;
Chemical compounds ;
Statistical analysis ;
Documentation ;
Exposure ;
Concentration(Composition) ;
Mortality ;
Fishkill ;
Growth stages ;
Fish physiology ;
Risk assessment ;
Multifactor probit analysis
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| ELBD ARCHIVE |
EPA 600-R-92-091 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| NTIS |
PB92-169655 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
vi, 94 pages : illustrations ; 28 cm |
| Abstract |
A comprehensive approach to predicting chronic toxicity from acute toxicity data was developed in which simultaneous consideration is given to concentration, degree of response, and time course of effect. A consistent endpoint (lethality) and degree of response (0%) were used to compare acute and chronic tests. Predicted no-effect concentrations were highly accurate 92% of the time (within a factor of 2.0 of the limits of the maximum acceptable toxicant concentrations for lethality) and did not vary by more than a factor of 4.8 when the technique was applied to a data base of 18 chemicals and 7 fish species. Growth effects can be predicted from chronic lethality, but reproductive effects should not be. |
| Notes |
Includes bibliographical references (page 61). Microfiche. |
