Record Display for the EPA National Library Catalog


Main Title Toxicity studies of selected chemicals. Task IV : the developmental toxicity of ethylene dibromide inhaled by rats and mice during organogenesis, final report /
Author Short, Robert Downs,
Other Authors
Author Title of a Work
Minor, Jan Lensfred.
Winston, Joseph M.
Ferguson, Brett.
Unger, Timothy M.
Lee, Cheng-Chun.
CORP Author Midwest Research Inst., Kansas City, Mo.;Environmental Protection Agency, Washington, D.C. Office of Toxic Substances.
Publisher U.S. Environmental Protection Agency, Office of Toxic Substances,
Year Published 1977
Report Number EPA 560/6-77-028; 68-01-3242; EPA-68-01-3242
Stock Number PB-273 267
OCLC Number 42242961
Subjects Ethylene dibromide--Toxicology
Additional Subjects Toxicity ; Bromides ; Bioassay ; Rats ; Mice ; Laboratory animals ; Pregnancy ; Exposure ; Dosage ; Dose rate ; Concentration(Composition) ; Respiration ; Congenital abnormalities ; Growth ; Toxic substances ; Ethylene dibromide ; Ethylene/di-bromo ; Teratogenesis ; Fetuses
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA 560-6-77-028 Headquarters Library/Washington,DC 08/28/2012
EJBD  EPA 560-6-77-028 Headquarters Library/Washington,DC 05/01/2015
EKBD  EPA-560/6-77-028 Research Triangle Park Library/RTP, NC 05/30/2003
ELBD  EPA 560-6-77-028 AWBERC Library/Cincinnati,OH 08/26/2016
ESAD  EPA 560-6-77-028 Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB-273 267 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation iii, 15 leaves : tables, graphs ; 28 cm
Ethylene dibromide (EDB) was administered at 20, 38, and 80 ppm by inhalation to pregnant Charles River CD rats and CD-1 mice for 23 hr/day. The exposures started on day 6 of gestation and lasted for a total of 10 days. Observations were made on maternal welfare and fetal development. The results of this study indicate that (1) EDB is more toxic in adult mice than adult rats, (2) adverse effects on maternal welfare, as measured by weight gain, feed consumption, and survival were observed in both mice and rats, (3) although morphological changes were observed in fetuses from dams exposed to EDB, these effects were observed at concentrations that also affected maternal welfare, and (4) EDB was judged to be only a weak teratogen with little primary effect on development.
"EPA 560/6-77-028." Contract No. 68-01-3242. Joseph Seifter, EPA Project Officer. Includes bibliographical references (leaves 14-15).