| Main Title |
Toxicity studies of selected chemicals. Task IV : the developmental toxicity of ethylene dibromide inhaled by rats and mice during organogenesis, final report / |
| Author |
Short, Robert Downs,
|
| Other Authors |
|
| CORP Author |
Midwest Research Inst., Kansas City, Mo.;Environmental Protection Agency, Washington, D.C. Office of Toxic Substances. |
| Publisher |
U.S. Environmental Protection Agency, Office of Toxic Substances, |
| Year Published |
1977 |
| Report Number |
EPA 560/6-77-028; 68-01-3242; EPA-68-01-3242 |
| Stock Number |
PB-273 267 |
| OCLC Number |
42242961 |
| Subjects |
Ethylene dibromide--Toxicology
|
| Additional Subjects |
Toxicity ;
Bromides ;
Bioassay ;
Rats ;
Mice ;
Laboratory animals ;
Pregnancy ;
Exposure ;
Dosage ;
Dose rate ;
Concentration(Composition) ;
Respiration ;
Congenital abnormalities ;
Growth ;
Toxic substances ;
Ethylene dibromide ;
Ethylene/di-bromo ;
Teratogenesis ;
Fetuses
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD ARCHIVE |
EPA 560-6-77-028 |
|
Headquarters Library/Washington,DC |
08/28/2012 |
| EJBD |
EPA 560-6-77-028 |
|
Headquarters Library/Washington,DC |
05/01/2015 |
| EKBD |
EPA-560/6-77-028 |
|
Research Triangle Park Library/RTP, NC |
05/30/2003 |
| ELBD |
EPA 560-6-77-028 |
|
AWBERC Library/Cincinnati,OH |
08/26/2016 |
| ESAD |
EPA 560-6-77-028 |
|
Region 10 Library/Seattle,WA |
03/23/2010 |
| NTIS |
PB-273 267 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
iii, 15 leaves : tables, graphs ; 28 cm |
| Abstract |
Ethylene dibromide (EDB) was administered at 20, 38, and 80 ppm by inhalation to pregnant Charles River CD rats and CD-1 mice for 23 hr/day. The exposures started on day 6 of gestation and lasted for a total of 10 days. Observations were made on maternal welfare and fetal development. The results of this study indicate that (1) EDB is more toxic in adult mice than adult rats, (2) adverse effects on maternal welfare, as measured by weight gain, feed consumption, and survival were observed in both mice and rats, (3) although morphological changes were observed in fetuses from dams exposed to EDB, these effects were observed at concentrations that also affected maternal welfare, and (4) EDB was judged to be only a weak teratogen with little primary effect on development. |
| Notes |
"EPA 560/6-77-028." Contract No. 68-01-3242. Joseph Seifter, EPA Project Officer. Includes bibliographical references (leaves 14-15). |
