Record Display for the EPA National Library Catalog


Main Title Teratology of guthion /
Author Short, Robert D. ; Minor, Jan L. ; Unger, Timothy M. ; Lee, Cheng-Chun
Other Authors
Author Title of a Work
Short, Robert D.
Baron, Ronald L.
CORP Author Midwest Research Inst., Kansas City, MO.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1978
Report Number EPA-600/1-78-056
Stock Number PB 288 457
OCLC Number 52473211
Additional Subjects Pesticides ; Cholinesterase inhibitors ; Toxicology ; Congenital abnormalities ; Assessments ; Rats ; Mice ; Lethal dosage ; Laboratory animals ; Experimental data ; Toxicity ; Dosage ; Pregnancy ; Reproduction(Biology) ; Tables(Data) ; Azinphosmethyl ; Teratology ; Lactation
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA 600-1-78-056 Headquarters Library/Washington,DC 08/09/2010
EJBD  EPA 600-1-78-056 c.1 Headquarters Library/Washington,DC 04/28/2014
EKBD  EPA-600/1-78-056 Research Triangle Park Library/RTP, NC 06/20/2003
ELBD RPS EPA 600-1-78-056 repository copy AWBERC Library/Cincinnati,OH 10/17/2014
NTIS  PB-288 457 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation iv, 22 p. ; 28 cm.
The purpose of this study was to assess the effects of Guthion, a pesticide with anticholinesterase activity, on development in rats and mice. A preliminary toxicity study with Guthion indicated that a 35 LD50 dose for virgin rats and a 10 day LD50 dose for virgin mice was between 4 and 8 mg/kg/day for both species. On the basis of this data, doses of 0, 1.25, 2.5, and 5.0 mg/kg/day were selected for the developmental study, which consisted of two phases. During the first phase, pregnant rats and mice were treated for 10 days starting on gestational day 6. The high dose affected maternal welfare only in rats. Guthion did not significantly increase in a dose-related manner any of the specific anomalies observed in either rats or mice. During the second phase, pregnant rats were treated from gestational day 6 to post-partum day 21. Dams in the high dose group were more sensitive to Guthion later in gestation with the result that deaths and signs of anticholinesterase toxicity increased during this time. Guthion also adversely affected maternal welfare in this group. As a result of Guthion toxicity, only one litter survived until weaning. The inability to dissociate toxicity in adult and developing animals suggests that Guthion has little primary effect on the development of rats or mice.
Project Officer: Ronald L. Baron. Midwest Research Institute "August 1978." "EPA-600/1-78-056."