Record Display for the EPA National Library Catalog


Main Title Metabolism and pharmacology of fluorine-containing compounds /
Author Lee, Cheng Chun,
Publisher Aerospace Medical Research Laboratories, Aerospace Medical Division, Air Force Systems Command, United States Air Force,
Year Published 1966
Report Number AMRL TR 66-110
OCLC Number 17552670
Subjects Fluorine--Toxicology ; Fluorides--Metabolism ; Fluorides--Physiological effect ; Fluorine--Compounds
Local Library Info
Library Local Subject Local Note
EJE Cas no. 7782-41-4
Library Call Number Additional Info Location Last
EJEM  QD181.F1L4 1966 OCSPP Chemical Library/Washington,DC 01/06/1995
Collation viii, 73 pages : illustrations ; 28 cm.
Includes bibliographic references (pages 72-73). Research supported by the Aerospace Medical Division, Air Force Systems Command, United States Air Force; report prepared by Midwest Research Institute, Kansas City, Missouri, under contract no. Contract Number: AF 33(615)-2472
Contents Notes
Acute inhalation, intraperitoneal and/or oral toxicities of AMOX and TAMA were determined in rats and mice. IP absorption was studied in rats. AMOX produced strong irritation resulting in pulmonary edema and hemorrhage after inhalation; and local denatured changes and accumulation of clear exudate after intraperitoneal injection. TAMA was less toxic on the weight basis. Both AMOX and TAMA were quickly absorbed after IP injection. Fluoride increased quickly in the blood and concentrated in various tissues especially in the thyroid, bone and teeth. Most of the administered fluoride was excreted in the urine and a considerable amount was also recovered in the feces.