Record Display for the EPA National Library Catalog

RECORD NUMBER: 37 OF 51

Main Title Neonatal Triethyltin Exposure Alters Adult Electrophysiology in Rats.
Author Dyer, Robert S. ; Howell, William E. ; Reiter, Lawrence W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1981
Report Number EPA-600/J-81-163;
Stock Number PB83-189589
Additional Subjects Toxicology ; Physiological effects ; Rats ; Laboratory animals ; Reprints ; Triethyltin
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  PB83-189589 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 17p
Abstract
In adults, triethyltin (TET) produces degeneration of white mater, edema, vacuolization of myelin and histoxic hypoxia. To determine the functional consequences of perinatal exposure to TET, albino rats were administered either 0,3,6, or 9 mg/kg TET on postnatal day 5. Upon reaching adulthood, the rats were implanted with electrodes for recording visual evoked potentials (VEPs) and hippocampal afterdischarges (ADs). In addition to these tests, 17 days of kindling trials were administered to the rats followed by testing with pentylenetetrazol and picrotoxin for seizure susceptibility.