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Main Title Updated mutagenicity and carcinogenicity assessment of cadmium : addendum to the Health Assessment Document for Cadmium (May 1981) EPA-600/8-81-023.
Author Anderson, Larry D. ; Bayad, Steven ; Lavappa, K. S. ; Tanchel, Nancy A. ; Thorslund, Todd W.
CORP Author Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment,
Year Published 1983
Report Number EPA-600/8-83-025A
Stock Number PB83-232280
OCLC Number 727064566
Subjects Cadmium--Environmental aspects.
Additional Subjects Cadmium ; Toxicology ; Exposure ; Aerosols ; Malignant neoplasms ; Lung ; Mutagenesis ; Carcinogenesis ; Toxic substances ; Cancer ; Health risks
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
ESAD  EPA 600-8-83-025A Region 10 Library/Seattle,WA 06/01/2011
NTIS  PB83-232280 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation iv, 144 p. : charts ; 28 cm.
This draft document evaluates the mutagenicity and carcinogenicity of cadmium, supplementing an earlier document (Health Assessment Document for Cadmium, May 1981) which dealt with all health effects. Since the earlier document was prepared, a rat inhalation carcinogenicity study has been reported and several epidemiology and mutagenicity papers have been published. This draft document tentatively concludes that: (1) there is evidence suggesting that cadmium and certain cadmium compounds are weakly mutagenic; (2) cadmium chloride aerosol induces lung cancer in rats; (3) injected cadmium salts induce injection site sarcomas and testicular tumors in both mice and rats; (4) there is limited epidemiologic evidence that inhaled cadmium induces prostate and/or lung cancer in highly exposed workers; (5) there is no evidence that cadmium is carcinogenic via ingestion, which is a major route of human exposure, and the upper-limit of potency via ingestion is at least 200 times less than via inhalation.
"Review Draft." "EPA-600/8-83-025A." "June 1983." Includes bibliographical references (p. 136-144).