Record Display for the EPA National Library Catalog

RECORD NUMBER: 19 OF 22

OLS Field Name OLS Field Data
Main Title Some Effects of Chronic Tritium Exposure during Selected Ages in the Rat.
Author Laskey, John W. ; Bursian., Steven J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, N.C.
Year Published 1976
Report Number EPA/600/J-76/061;
Stock Number PB-268 119
Additional Subjects Tritium ; Radiation effects ; Radiobiology ; Dose rate ; Age ; Rats ; Laboratory animals ; Experimental data ; Exposure ; Radioactive isotopes ; Irradiation ; Radiation dosage ; Pregnancy ; Tables(Data) ; Pathology ; Reproductive system ; Endocrine glands ; Neurochemistry ; Reprints
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB-268 119 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 10p
Abstract
To assess the implication of age at the time of exposure to chronic irradiation, rats were exposed to constant tritium (HTO) activities of 10 microcuries/ml of body water for 42 days beginning either on the first day of pregnancy or at birth, or at 42 days or 74 days of age. This activity level provided a calculated whole-body dose rate of 3 rad/day. The indicators of radiobiologic damage employed were reproductive, endocrine, and neurochemical parameters and were assessed at 49, 120, or 300 days of age. A significant reduction in the testes weight and sperm content in rats exposed either from the first day of pregnancy or birth was evident upon examination at 49 days of age. Females exposed from the first day of pregnancy had a significant reduction in their F2 litter size and an increase in the number of resorbed embryos. Analysis for norepinephrine (NE) and dopamine (DA) concentration in the brain and follicle-stimulating hormone (FSH) concentration in the pituitary was performed at 49 and 300 days.