Record Display for the EPA National Library Catalog


Main Title Carcinogenicity and Pesticides: Biological Issues in Extrapolation.
Author Yang, R. S. H. ; Huff, J. ; Germolec, D. R. ; Luster, M. I. ; Simmons, J. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;National Toxicology Program, Research Triangle Park, NC. ;PATHCO, Inc., Research Triangle Park, NC.
Publisher 1989
Year Published 1989
Report Number EPA/600/D-89/158;
Stock Number PB90-119215
Additional Subjects Pesticides ; Exposure ; Carcinogenicity tests ; Toxic substances ; Risk assessment ; Species specificity ; Dose response relationships ; Pharmacokinetics ; Synergism ; Lethal doses ; Sex factors
Library Call Number Additional Info Location Last
NTIS  PB90-119215 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 39p
Approximately 41% (26/63) of the pesticides evaluated in the chronic toxicity and carcinogenicity studies of the National Toxicology Program (NTP) showed varying degrees of carcinogenicity. Since those chemicals nominated to the NTP for carcinogenicity studies usually represent a sampling of potentially 'problem' chemicals, this ratio does not implicate the actual percentage of carcinogenic chemicals among all pesticides. In general, results from epidemiological studies are of limited value in prevention and have been done on few pesticides. To assess potential risks of chemicals to humans, extrapolation of the findings in laboratory animals to possible health effects in humans is inevitable. Several important biological issues must be considered in such a process; these include extrapolation between doses, species (including strain and sex), routes of administration and exposure regimens (e.g., intermittent vs.constant rate). Any imperfection in such a process (e.g., hazard identification and risk assessment of any given chemical or other agent) must be taken into consideration during extrapolation.