| Main Title |
Macromolecular Adduction by Trichloroacetonitrile in the Fischer 344 Rat Following Oral Gavage. |
| Author |
Lin, E. L. C. ;
Reddy, T. V. ;
Daniel, F. B. ;
|
| CORP Author |
Environmental Monitoring Systems Lab., Cincinnati, OH. |
| Publisher |
c1992 |
| Year Published |
1992 |
| Report Number |
EPA/600/J-92/368; |
| Stock Number |
PB93-107134 |
| Additional Subjects |
DNA adducts ;
Toxicity ;
Blood proteins ;
Rats ;
Deoxyribonucleic acids ;
Dose-response relationships ;
Liver ;
Kidney ;
Stomach ;
Liquid chromatography ;
Reprints ;
Nitrile/trichloroaceto
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB93-107134 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
Male Fisher 344 rats were administered 1- or 2-((14)C)trichloroacetonitrile (TCAN) by oral gavage. DNA was isolated from the liver, kidneys and stomach and several protein fractions (globin, albumin and globulins) were isolated from blood. The stomach exhibited the highest level of DNA binding, followed in order by the liver and kidney. TCAN binding level was higher in DNA isolated from rats killed at 24 h than at 4 h after administration. Radioactivity associated with DNA was not incorporated into the nitrogen bases (i.e. via de novo synthesis) and a covalent binding index (micromol chemical bound/mol nucleotide phosphate per mmol/kg body wt. of chemical administered) of 30 - 120 was observed for various tissues. |
