Record Display for the EPA National Library Catalog
RECORD NUMBER: 4 OF 9| Main Title | Genotoxic Properties of Haloacetonitriles: Drinking Water By-Products of Chlorine Disinfection. | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Author | Daniel, F. B. ; Schenck, K. M. ; Mattox, J. K. ; Lin, E. L. C. ; Haas, D. L. ; | |||||||||||
| CORP Author | Health Effects Research Lab., Research Triangle Park, NC. | |||||||||||
| Year Published | 1986 | |||||||||||
| Report Number | EPA/600/J-86/342; | |||||||||||
| Stock Number | PB87-180782 | |||||||||||
| Additional Subjects | Halogen organic compounds ; Acetonitriles ; Chlorination ; Water treatment ; Disinfection ; Public health ; Bioassay ; Carcinogens ; Hazards ; Toxicity ; Humans ; Cells(Biology) ; Exposure ; Reprints ; Drinking water ; Water pollution effects(Humans) | |||||||||||
| Holdings |
|
|||||||||||
| Collation | 9p | |||||||||||
| Abstract | Chlorinated and brominated haloacetonitriles (HAN), known drinking water contaminants which form during chlorine disinfection, were investigated for genotoxic activity. The HAN produced DNA strand breaks in cultured human lymphoblastic (CCRF-CEM) cells, bound to the nucleophilic trapping agent 4-(p-nitrobenzyl) pyridine and formed a covalent bond to polyadenylic acid in a cell-free reaction system. Thus, the authors have demonstrated that these chemicals are genotoxic, which would indicate a potential for carcinogenic activity and for human health hazard. |