Record Display for the EPA National Library Catalog


Main Title Intramembrane-Cleaving Proteases (I-CLiPs) [electronic resource] /
Author Hooper, Nigel M.
Other Authors
Author Title of a Work
Lendeckel, Uwe.
Publisher Springer Netherlands,
Year Published 2007
Call Number RC321-580
ISBN 9781402063114
Subjects Medicine ; Neurosciences ; Cytology
Internet Access
Description Access URL
Collation IX, 142 p. online resource.
Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes
The Site-2 Protease at Ten -- Signal Peptide Peptidases -- GXGD-Type Intramembrane Proteases -- Rhomboid Intramembrane Serine Proteases -- Proteases of the Rhomboid Family in the Yeast Saccharomyces Cerevisiae -- ?-Secretase And Alzheimer'S Disease -- ?-Secretase Mediated Proteolysis: At the Cutting Edge of Notch Signaling. In recent years a growing number of proteases have been identified that catalyse peptide bond hydrolysis in the plane of the cellular membrane. These so-called 'intramembrane-cleaving proteases' (I-CLiPs) are involved in a diverse range of cellular processes, including cell regulation, signalling, quorum sensing, protein processing, lipid metabolism and the unfolded protein response. Some I-CLiPs play critical roles in diseases such as Alzheimer's and viral infection. The authors, who are all world leaders in this exciting field of cell biology, provide an overview of the various proteases including recent data derived from the structural determination of some of the I-CliPs, and discuss the various roles that these proteases play in biology and disease. The aim of this book is to provide an update on this emerging group of unusual but important proteases for both the specialist and those with a broader interest in proteases. Amongst the target audience will be protease researchers, enzymologists, those working in academia and the pharmaceutical industry on biological processes and diseases involving I-CLiPs.