| Contents Notes |
Of Volume 1 -- A personal and historical perspective on drug metabolism / Gerald T. Miwa and Arthur K. Cho -- Fundamentals of organic chemistry as applicable to the biotransformation of foreign compounds / Antonia F. Stepan and Amit S. Kalgutkar -- Functional group biotransformations / R. Scott Obach -- Drugs as victims and perpetrators and the pharmacokinetic concept of maximum exposure / Brian W. Ogilvie and Andrew Parkinson -- Drug-metabolizing enzymes: a group of promiscuous catalysts / Qiang Ma and Anthony Y.H. Lu -- Unusual metabolic reactions and pathways / F. Peter Guengerich and Emre M. Isin -- Role of biotransformation in drug discovery / Ronald E. White -- Role of metabolism in drug development / Suresh K. Balani -- Role of biotransformation in pesticide discovery and development / Michael E. Krolski and Stephen C. Dacus -- Role of cytochrome P450 enzymes in biotransformation / Paul R. Ortiz de Montellano -- Major human conjugative drug-metabolizing enzymes / Daniel R. Albaugh and Michael B. Fisher -- Metabolic activation and associated drug toxicity / Thomas A. Baillie -- In vitro experimental models for studying drug biotransformation / Tonika Bohnert and Liang-Shang Gan -- In vivo experimental models for studying drug biotransformation / W. Griffith Humphreys -- Contents of Volume 2 -- Theory and instrumentation of mass spectrometry and its application to drug metabolism / Stacy L. Gelhaus and Ian A. Blair -- Mass spectral interpretation / Li-Kang Zhang and Birendra N. Pramanik -- Computational approaches in drug biotransformation studies: metabolite prediction / Nigel J. Waters and Michelle K. Dennehy. High-throughput metabolite detection and quantitative/qualitative bioanalysis / Donghui Cui and Sean Yu -- Metabolic stability screen in drug discovery / Chuang Lu -- Application of triple-quadrupole and its hybrid mass spectrometers for the identification of drug metabolites / Zhi-Yi Zhang, Chandra Prakash, and Lin Xu -- Role of ion trap LC-MS techniques for the identification of drug metabolites / Robert D. Pelletier and W. George Lai -- Drug metabolite identification with high-resolution mass spectrometry / Haiying Zhang and Mingshe Zhu -- Strategies for the identification of unusual and novel metabolites using derivatization, hydrogen/deuterium exchange (HDX), and liquid chromatography-nuclear magnetic resonance (LC-NMR) spectroscopy techniques / Amin Kamel, Shawn Harriman, and Chandra Prakash -- The use of nanoelectrospray mass spectrometry for the quantitation of metabolites in the absence of synthetic standards / Jing-Tao Wu -- Quantitation of drug metabolites by radioactivity detection including accelerator mass spectrometry (AMS) / Angus N.R. Nedderman and Mark E. Savage -- Application of quantitative NMR in drug metabolism studies / Abdul E. Mutlib -- Early assessment of exposure of drug metabolites in humans using mass spectrometry / Natalia A. Penner, Joanna Zgoda-Pols, and Chandra Prakash -- Profiling and characterization of bioactive substances of herbal medicine and their metabolites using mass spectrometry -- Xiaoyan chen -- Application of in silico metabolism and environmental degradation data to support chemical PBT assessment / Sabcho Dimitrov, Gilman Veith, and Ovanes Mekenyan. |
