Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effects of Chronic Manganese (Mn3O4) Exposure on Selected Reproductive Parameters in Rats.
Author Laskey, J. W. ; Rehnberg, G. L. ; Hein, J. F. ; Carter, S. D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1982
Report Number EPA-600/J-81-328;
Stock Number PB84-174366
Additional Subjects Managanese ; Toxicology ; Exposure ; Rats ; Laboratory animals ; Reproduction(Biology) ; Diets ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB84-174366 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 13p
Long-Evans rats were chronically exposed to dietary manganese beginning on d 1 of gestation and continuing through 224 d of age. Dietary concentrations of manganese were 350, 1050, and 3500 ppm and were applied in either normal Fe 240 (ppm) or a low-Fe (20 ppm) basal diet. General toxic effects were apparent in young animals at a dietary dose of 3500 ppm Mn and were enhanced by concomitant Fe deficiency. Fertility was reduced in the group exposed to 3500 ppm Mn with a diet containing sufficient Fe. Male reproductive development was delayed by Mn treatment, as measured by testes weight, sperm count, and serum follicle-stimulating hormone and testosterone concentrations.