Record Display for the EPA National Library Catalog


Main Title Effects of Lindane and Linuron on Calcium Metabolism, Bone Morphometry and the Kidney in Rats.
Author Andrews, J. E. ; Gray, L. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/047;
Stock Number PB90-217480
Additional Subjects Chlorobenzenes ; Calcium ; Metabolism ; Toxicology ; Bones ; Kidney ; Hormones ; Body weight ; Tables(Data) ; Blood chemical analysis ; Urine ; Reprints ; Linuron ; Organ weight
Library Call Number Additional Info Location Last
NTIS  PB90-217480 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
The effects of lindane and linuron on calcium metabolism, bone morphometry and the kidney. Experiments were performed to investigate the effects of lindane and linuron on calcium metabolism, femur morphometry and nephrotoxicity. Long-Evans hooded rats were dosed daily for 10 weeks with 0, 10 or 20 mg lindane or 10, 20 or 40 mg linuron/kg body weight beginning at weaning. Lindane significantly decreased urinary calcium concentration, serum alkaline phosphatase concentration and the cross-sectional medullary area of the bone. Lindane was nephrotoxic at both dose levels as demonstrated by elevated kidney weights, kidney-to-body-weight ratios, enzymuria, tubule regeneration and hyaline droplet degeneration. Linuron significantly reduced medullary cross-sectional area at the two higher dose levels and decreased the total femur cross-sectional area at the highest dose level in the absence of effects on calcium excretion. Femur density and strength were also significantly reduced at the highest dose level of linuron. Neither compound affected the serum concentrations of parathyroid hormone or 1,25-dihydroxy Vitamin D3.