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Main Title Toxicity equivalency factors for PCBs
Author Barnes, D. ; Alford-Stevens, A. ; Birnbaum, L. ; Kutz, F. W. ; Wood, W.
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher Health Effects Research Laboratory, U.S Environmental Protection Agency ;
Year Published 1991
Report Number PB92-113349 ; EPA/600/J-91/272
Stock Number PB92-113349
OCLC Number 55048991
Subjects Polychlorinated biphenyls--Environmental aspects ; Polychlorinated biphenyls--Toxicology ; Pollution--Environmental aspects
Additional Subjects Toxicity ; Polychlorobiphenyl compounds ; Health hazards ; Risk assessment ; Mixtures ; Meetings ; Exposure ; Reprints ; Toxicity equivalency factors ; Chlorinated dibenzo-p-dioxins ; Chlorinated dibenzofurans
Library Call Number Additional Info Location Last
ESAD  EPA 600-J-91-272 Region 10 Library/Seattle,WA 04/30/2004
NTIS  PB92-113349 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12 p. : ill.
In December 1990 the U.S. Environmental Protection Agency sponsored a workshop to discuss the applicability of an interim 'toxicity equivalency factor' (TEF) approach to assessing risks posed by exposures to complex mixtures of polychlorinated biphenyls (PCBs). The group concluded that application of the TEF approach to PCBs would be less straightforward than it was in the case of chlorinated dibenzo-p-dioxins and dibenzofurans (CDDs/CDFs). It appears that 'dioxin'-like properties of some PCB congeners are amenable to a TEF treatment that is compatible with that used for CDDs/CDFs. Such a scheme also seems to have utility in assessing risks to wildlife. Other non-'dioxin'-like toxic endpoints (e.g., neurotoxicity) appear to have a different structure-activity-related mechanism-of-action that requires a separate TEF scheme. The workshop identified data gaps in toxicology and analytical chemistry that hinder adoption of proposed TEF schemes for PCBs at this time. (Copyright (c) 1991 by Academic Press, Inc.)
"EPA/600/J-91/272." "PB92-113349." Contains bibliographic references at end of paper.