Record Display for the EPA National Library Catalog


Main Title Human Upper Respiratory Tract Responses to Inhaled Pollutants with Emphasis on Nasal Lavage.
Author Koren, H. S. ; Devlin, R. B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Clinical Research Branch.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-93/120;
Stock Number PB93-181089
Additional Subjects Air pollution effects(Humans) ; Respiratory system ; Nose(Anatomy) ; Indoor air pollution ; Signs and symptoms ; Neutrophils ; Inflammation ; Reprints ; Nasal lavage ; Sick buildings ; Volatile organic compounds
Library Call Number Additional Info Location Last
NTIS  PB93-181089 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
A set of symptoms has been described during the past two decades which has been called the 'sick building syndrome'. These symptoms include eye, nose, and throat irritation; headache; mental fatigue; and respiratory distress. It is likely that volatile organic compounds (VOC) present in synthetic materials used in homes and office buildings contribute to these symptoms. However, there have been few studies in which humans have been exposed to known amounts of VOC under carefully controlled conditions. In the study 14 subjects have been exposed to a mixture of VOC (25 mg/cu m total hydrocarbon) representative of what is found in new homes and office buildings. Since irritation of the nose and throat are symptoms often associated with the upper respiratory tract and may result from an inflammatory response in the upper airways, the authors have used nasal lavage to monitor neutrophil (PMN) influx into the nasal passages following exposure to VOC. The authors report statistically significant increases in PMNs both immediately after a four hour exposure to VOC, as well as 18 hours later.