Record Display for the EPA National Library Catalog


Main Title Subchronic 90 Day Toxicity of Dichloroacetic and Trichloroacetic Acid in Rats.
Author Mather, G. G. ; Exon, J. H. ; Koller, L. D. ;
CORP Author Idaho Univ., Moscow. ;Oregon State Univ., Corvallis. School of Veterinary Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/425;
Stock Number PB91-171801
Additional Subjects Toxicity ; Dichloroacetate ; Trichloroacetic acid ; Dose-response relationships ; Mixed function oxidases ; Blood proteins ; Organ weight ; Body weight ; Alkaline phosphatase ; Alanine aminotransferase ; Pathology ; Immune system ; Statistical analysis ; Blood chemistry ; Enzyme induction ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB91-171801 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
Male Sprague-Dawley rats were treated with either dichloroacetic acid (DCA) or trichloroacetic acid (TCA) in the drinking water at levels of 0, 50, 500 and 5000 ppm for a period of 90 days to determine the toxicities associated with subchronic exposure. All animals were sacrificed and examined for gross and histopathologic lesions, serochemical changes, immune dysfunction, hepatic peroxisomal and mixed function oxidase enzyme induction and organ-body weight changes. Animals treated with DCa had decreased body weight gains (500 and 5000 ppm) and decreased total serum protein (all doses). Rats given either TCA (5000 ppm) or DCA (500 or 5000 ppm) had increased liver and kidney organ to body weight ratios. Rats offered DCA had significantly elevated alkaline phosphatase (500 and 5000 ppm) and alanine-amino transferase (5000 ppm). No consistent immunotoxicity was observed in animals exposed to either compound. Rats treated with 5000 ppm TCA or DCA had significantly increased hepatic peroxisomal beta-oxidation activity. (Copyright (c) 1990 Elsevier Scientific Publishers Ireland Ltd.)