Record Display for the EPA National Library Catalog

RECORD NUMBER: 2 OF 22

OLS Field Name OLS Field Data
Main Title CASE (Computer Automated Structure Evaluation) Study of In vitro Inhibition of Spareteine Monooxygenase.
Author Klopman, G. ; Venegas, R. E. ;
CORP Author Case Western Reserve Univ., Cleveland, OH. Dept. of Chemistry.;Health Effects Research Lab., Research Triangle Park, NC.;Office of Naval Research, Arlington, VA.
Publisher c1986
Year Published 1986
Report Number EPA-R-812264; EPA/600/J-86/513;
Stock Number PB90-106394
Additional Subjects Enzyme inhibitors ; In vitro analysis ; Tables(Data) ; Reprints ; Expert systems ; Mixed function oxidases ; Sparteine monooxygenase ; Computer automated structure evaluation(CASE) ; Structure-activity relationship
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB90-106394 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/1990
Collation 21p
Abstract
The Computer Automated Structure Evaluation program (CASE) has been used to analyze the in vitro inhibition of sparteine monooxygenase. A significant correlation between the Log10 P (1-octanol/water) of the 74 drugs studied and their inhibitory potency is observed.