Record Display for the EPA National Library Catalog

RECORD NUMBER: 23 OF 33

Main Title Peroxyacetyl Nitrate: Measurement of Its Mutagenic Activity Using the 'Salmonella'/Mammalian Microsome Reversion Assay.
Author Kleindienst, T. E. ; Shepson, P. B. ; Edney, E. O. ; Claxton, L. D. ;
CORP Author Northrop Services, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/237;
Stock Number PB86-136181
Additional Subjects Bacteria ; Toxicology ; Exposure ; Concentration(Composition) ; Reprints ; Salmonella typhimurium ; CAS 2278-22-0 ; Peroxyacetyl nitrate ; Mutagenesis
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NTIS  PB86-136181 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 7p
Abstract
Exposures of Salmonella typhimurium strain TA100, with and without S9 metabolic activation, to low ppm levels of pure peroxyacetyl nitrate (PAN) in the gas phase were conducted. Measurements of the gas phase PAN exposure concentration and the concentration of its decomposition products in surrogate test media led to a measured mutagenic activity of 34 plus or minus 5 revertants/micromoles. The data indicated that PAN is a relatively weak direct-acting mutagen with TA100.