Record Display for the EPA National Library Catalog


Main Title Survival Curves and Incidence of Neoplastic and Non-Neoplastic Disease in SENCAR Mice.
Author Conti, C. J. ; Clapp, N. ; Klein-Szanto, A. J. P. ; Nesnow, S. ; Slaga, T. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Texas Univ. System Cancer Center, Houston. ;Oak Ridge Associated Universities, Inc., TN.
Year Published 1985
Report Number EPA/600/J-85/268;
Stock Number PB86-160025
Additional Subjects Neoplasms ; Diseases ; Laboratory animals ; Incidence ; Survival ; Mice ; Reprints ; Carcinogenesis
Library Call Number Additional Info Location Last
NTIS  PB86-160025 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
The survival curves and the incidence of spontaneous diseases were studied in a population of SENCAR mice, a stock derived by a selected breeding protocol for enhanced susceptibility to chemical carcinogenesis in the skin. SENCAR mice proved to be as long-lived as other mouse strains or stocks, including one of their parental lines, Charles River CD-1. The most frequently occurring neoplasias in SENCAR mice were lymphoma, myeloid leukemia and reticulum cell sarcoma. Other frequently occurring neoplastic diseases included lung adenomas and carcinoma and mammary gland carcinoma. However, the incidence of these tumors was not higher than the incidence in CD-1 mice or other mouse strains or stocks.