| Main Title |
Use of Molecular Negentropy to Encode Structure Governing Biological Activity. |
| Author |
Kier, L. B. ;
|
| CORP Author |
Virginia Commonwealth Univ., Richmond.;Environmental Research Lab.-Duluth, MN. |
| Year Published |
1980 |
| Report Number |
EPA-R-808923; EPA-600/J-80-436; |
| Stock Number |
PB84-116714 |
| Additional Subjects |
Drugs ;
Molecules ;
Tissues(Biology) ;
Information ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB84-116714 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
A drug molecule is considered to be an information source with an information content available to receptive tissue. In nonspecific interactions, much of the information content has quality as judged by the receptor. Quantitation of the information content using Shannon's equation gives the molecular negentropy. This index is shown to rank molecules according to symmetry and to encode structural characteristics influencing physical properties and biological activity in certain cases. |
