Record Display for the EPA National Library Catalog


Main Title Effects on the Fetus of Maternal Nitrofen Exposure in the Protein-Deprived Rat.
Author Zeman, F. J. ; Hoogenboom, E. R. ; Chase-Deesing, C. ; Kavlock, R. J. ; Semple, J. L. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;California Univ., Davis.
Year Published 1986
Report Number EPA/600/J-86/073;
Stock Number PB86-212669
Additional Subjects Toxicology ; Exposure ; Rats ; Pregnancy ; Diet ; Laboratory animals ; Reprints ; Protein deprivation ; Nitrofen
Library Call Number Additional Info Location Last
NTIS  PB86-212669 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 15p
The separate and combined effects of protein deprivation and nitrofen exposure were studied in the pregnant rat. Animals were fed diets containing 24, 8, 6 or 4% casein throughout gestation. Within each diet group, sub-groups were gavage-fed with 12.5 (lower dose) and 25 (higher dose) mg nitrofen/kg body weight or with oil carrier only on days 7-21 of gestation. Dams were weighed and food intake was measured daily. On day 21 of gestation, cesarean-derived pups were examined for congenital anomalies and dissected for determination of organ weights. Skeletons were alizarin stained and examined for skeletal anomalies and developmental stage. No effects on the skeleton or gross congenital anomalies were seen. Fetal, size and weights of liver, kidney, intestine, heart, lung and brain were reduced with decreasing casein content of the diet and as a result of the higher dose of nitrofen.