Record Display for the EPA National Library Catalog


Main Title Effects of Neonatal Methylmercury Exposure on Development of Nucleic Acids and Proteins in Rat Brain: Regional Specificity.
Author Slotkin, T. A. ; Pachman, S. ; Kavlock, R. J. ; Bartolome, J. ;
CORP Author Duke Univ. Medical Center, Durham, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA-R-811621; EPA/600/J-85/193;
Stock Number PB86-120334
Additional Subjects Proteins ; Nucleic acids ; Toxicology ; Brain ; Exposure ; Rats ; Laboratory animals ; Reprints ; Mercury/methyl
Library Call Number Additional Info Location Last
NTIS  PB86-120334 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 5p
Exposure of neonatal rats to methylmercury (1 or 2.5 mg/kg SC daily) during the preweaning period caused regionally-specific alterations in DNA, RNA and protein content in brain. In midbrain + brainstem, where neuronal replication and differentiation conclude early, reduced DNA content was prominent at either dose and was apparent well before evidence of general body growth impairment; small deficits in protein content and brain region weight were seen. In contrast, cerebral cortex showed an elevation of DNA in the high dose group and a tendency toward supranormal RNA values at either dose.