Record Display for the EPA National Library Catalog


Main Title 2-Methylhexanoic Acid Developmental Toxicity Testing.
Author Narotsky, M. G. ; Kavlock, R. J. ;
CORP Author ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher Jun 91
Year Published 1991
Report Number EPA-68-02-4450; EPA/600/1-91/002;
Stock Number PB91-197418
Additional Subjects Toxicity ; Reproduction(Biology) ; Teratogens ; Dose-response relationships ; Survival ; Skeleton ; Weight loss ; Respiration ; Tables(Data) ; Rats ; 2-Methylhexanoic acid
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
NTIS  PB91-197418 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 22p
As part of an investigation of the developmental effects and structure-activity relationships of aliphatic acids, 2-methylhexanoic acid was administered by gavage to Sprague-Dawley rats on gestation days 6-15 at doses of 0, 300, and 400 mg/kg/day. The dams were allowed to deliver and their litters were examined through postnatal day 6. Pups that were found dead were examined for soft-tissue alterations. On day 6, two survivors per litter were preserved for skeletal examination. Maternal toxicity was demonstrated at both 300 and 400 mg/kg by weight loss and altered respiration (rales, dyspnea). In spite of the maternal toxicity present, there were no clear toxic effects on development; litter size, pre- and postnatal viability, and pup weights were unaffected by treatment. Skeletal examinations of selected pups yielded inconclusive data; a slight increase in the incidence of lumbar ribs was present a 400 mg/kg, but was not clearly attributable to treatment.