Record Display for the EPA National Library Catalog


Main Title Maturation of the Sympathetic Nervous System: Role in Neonatal Physiological Adaptations and in Cellular Development of Peripheral Tissues.
Author Slotkin, T. A. ; Kudlacz, E. M. ; Hou, Q. C. ; Seidler, F. J. ;
CORP Author Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC.;Public Health Service, Rockville, MD.
Publisher c1990
Year Published 1990
Report Number EPA-R-813769, PHS-NS-06233; EPA/600/D-90/041;
Stock Number PB90-221730
Additional Subjects Animal physiology ; Neural transmission ; Adrenal medulla ; Catecholamines ; Growth(Biology) ; Reprints ; Newborn animals ; Isoproterenol
Library Call Number Additional Info Location Last
NTIS  PB90-221730 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
It is obvious that the development of the nervous system is marked by the progression from immaturity of function to the acquisition of neurotransmission and integrated control of synaptic activity. However, there is an increasing realization that neural function in the fetus and neonate also serves specialized needs which are particular to development, and that the onset of maturity equally represents the loss of these unique patterns of neural activity. Nowhere is this more evident than in the sympathetic nervous system and its endocrine counterpart, the adrenal medulla. This review will detail recent work which demonstrates how catecholamines released first by the adrenal, and later by neurons, mediate the transition from fetal to neonatal physiological function as well as the subsequent programming of postsynaptic reactivity and cellular differentiation in target tissues. The rat has been chosen for study as this species is altricial, and therefore develops neural function relatively late. Thus, in the rat many fetal neural characteristics persist into the postnatal period.