Record Display for the EPA National Library Catalog


Main Title Model for Comparison of Animal and Human Alveolar Dose and Toxic Effect of Inhaled Ozone.
Author Hatch, G. E. ; Koren, H. ; Aissa, M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1988
Report Number EPA/600/D-88/039;
Stock Number PB88-171194
Additional Subjects Ozone ; Dosimetry ; Exposure ; Toxicity ; Respiratory diseases ; Mathematical models ; Air pollution ; Lung ; Toxic substances ; BAL(Broncho Alveolar Lavage)
Library Call Number Additional Info Location Last
NTIS  PB88-171194 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 22p
Present models for predicting human pulmonary toxicity of ozone from the toxic effects observed in animals rely on dosimetric measurements of ozone mass balance, and species comparisons of tissue protective mechanisms against ozone. The goal of the present study was to identify a method to directly compare ozone dose and effect in animals and humans using bronchoalveolar lavage (BAL) fluid markers. Feasibility of estimating ozone dose to lung alveoli was demonstrated through assay of reaction products of oxygen-18 labeled ozone in lung surfactant and macrophage pellets of rabbits. Feasibility of using BAL protein measurements to quantify the ozone toxic response in humans was demonstrated by the finding of significantly increased BAL protein in 10 subjects exposed to 0.4 ppm ozone for 2 hr with intermittant periods of heavy exercise.