Record Display for the EPA National Library Catalog


Main Title Inflammatory Response in Human Lung Exposed to Ambient Levels of Ozone.
Author Koren, H. S. ; Devlin, R. B. ; Graham, D. E. ; McDonnell, W. F. ; Mann, R. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Clinical Research Branch. ;North Carolina Univ. at Chapel Hill. School of Medicine.
Year Published 1988
Report Number EPA/600/D-88/102;
Stock Number PB88-213202
Additional Subjects Ozone ; Lungs ; Exposure ; Inflammation ; Concentration(Composition) ; Air pollution effects(Humans) ; Health effects ; Inhalation ; Health hazards ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB88-213202 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
Although ozone (O3) has been shown to induce inflammation in the lungs of animals, very little is known about its inflammatory effects on humans. In the study, eleven healthy non-smoking males, ages 18-35 were exposed once to 0.4 ppm O3 and once to filtered air for two hours with intermittent exercise. Preliminary results from a study addressing the effect of extended O3 exposure (7 hours, 0.1 ppm) indicated an inflammatory response in the lower airway evidenced by a 4.8-fold increase in the percent of PMN in the BAL. The findings show that an acute exposure to 0.4 ppm O3 as well as an extended exposure result in increased levels of inflammatory cells potentially capable of producing damage in the lower airways of humans.