Record Display for the EPA National Library Catalog


Main Title Some Pharmacokinetic and Metabolic Factors Affecting the Neonatal Toxicity of Chlorinated Hydrocarbons Found in the Great Lakes.
Author Kitchin, K. T. ; Kacew, S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Experimental Biology Div. ;Ottawa Univ. (Ontario). Dept. of Pharmacology.
Year Published 1987
Report Number EPA/600/D-87/004;
Stock Number PB87-147104
Additional Subjects Chlorohydrocarbons ; Toxicity ; Food chains ; Wildlife ; Fishes ; Contaminants ; Great Lakes ; Toxic substances ; Pharmakinetics ; Water pollution effects(Animals) ; Bioaccumulation
Library Call Number Additional Info Location Last
NTIS  PB87-147104 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 56p
Industrialization has resulted in the emission of a wide variety of organic chemicals into the biosphere. Despite the original source of the organic contaminant, these chemicals have managed to enter drinking water supplies and bioaccumulate in food chains. Of particular interest are the organic contaminants which have been identified in fish and wildlife in the Great Lakes Basin. As this waterway system functions as an important source of drinking water for North Americans, concern has been raised with respect to toxicity and bioaccumulation of these chemicals. Although a vast number of environmental pollutants have thus far been identified, this chapter will focus on just ten chemicals, principally chlorinated benzenes, octachlorostyrene and hexachlorobutadiene. The adult, fetal and neonatal toxicities of these compounds are discussed with emphasis on metabolic and pharmacokinetic factors which influence them.