Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Ozone Uptake in Awake Sprague-Dawley Rats.
Author Wiester, M. J. ; Williams, T. B. ; King, M. E. ; Menache, M. G. ; Miller, F. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1987
Report Number EPA/600/J-87/366;
Stock Number PB88-223284
Additional Subjects Ozone ; Rats ; Respiratory system ; Laboratory animals ; Concentration(Composition) ; Exposure ; Reprints ; Inhalation ; Biological effects ; Health effects ; Sprague-Dawley rats
Library Call Number Additional Info Location Last
NTIS  PB88-223284 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 12/29/1988
Collation 11p
Knowledge of ozone (O3) uptake in rats is integral to efforts to quantitatively extrapolate animal data to man. The authors have measured percent uptake 30 adult Sprague Dawley rats exposed, nose only, for 1 hr to 0.3, 0.6 or 1.0 ppm O3. Resting breathing measurements were obtained by plethysmography while changes in ozone, oxygen, and carbon dioxide, due to animal breathing, were computed. Ozone uptake was calculated by a fractional deposition technique, i.e. O3 in vs. O3 out. Pulmonary O3 uptake was found to be approximately 40 percent of that inspired. The value did not vary over time nor was it affected by O3 concentration. Although ozone uptake did not appear to be influenced by ventilatory changes within normal breathing limits, it was positively correlated with respiratory gas exchange. The quantitative retention of O3 by the respiratory epithelium increased proportionally with O3 concentration and minute volume. (Copyright (c) 1987 Academic Press, Inc.)