||Effects of Neonatal Methylmercury Exposure on Development of Nucleic Acids and Proteins in Rat Brain: Regional Specificity.
Slotkin, T. A. ;
Pachman, S. ;
Kavlock, R. J. ;
Bartolome, J. ;
||Duke Univ. Medical Center, Durham, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Nucleic acids ;
Laboratory animals ;
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Exposure of neonatal rats to methylmercury (1 or 2.5 mg/kg SC daily) during the preweaning period caused regionally-specific alterations in DNA, RNA and protein content in brain. In midbrain + brainstem, where neuronal replication and differentiation conclude early, reduced DNA content was prominent at either dose and was apparent well before evidence of general body growth impairment; small deficits in protein content and brain region weight were seen. In contrast, cerebral cortex showed an elevation of DNA in the high dose group and a tendency toward supranormal RNA values at either dose.