Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effects of Neonatal Methylmercury Exposure on Development of Nucleic Acids and Proteins in Rat Brain: Regional Specificity.
Author Slotkin, T. A. ; Pachman, S. ; Kavlock, R. J. ; Bartolome, J. ;
CORP Author Duke Univ. Medical Center, Durham, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA-R-811621; EPA/600/J-85/193;
Stock Number PB86-120334
Additional Subjects Proteins ; Nucleic acids ; Toxicology ; Brain ; Exposure ; Rats ; Laboratory animals ; Reprints ; Mercury/methyl
Library Call Number Additional Info Location Last
NTIS  PB86-120334 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 5p
Exposure of neonatal rats to methylmercury (1 or 2.5 mg/kg SC daily) during the preweaning period caused regionally-specific alterations in DNA, RNA and protein content in brain. In midbrain + brainstem, where neuronal replication and differentiation conclude early, reduced DNA content was prominent at either dose and was apparent well before evidence of general body growth impairment; small deficits in protein content and brain region weight were seen. In contrast, cerebral cortex showed an elevation of DNA in the high dose group and a tendency toward supranormal RNA values at either dose.