||Cell Number and Size in Selected Organs of Fetuses of Rats Malnourished and Exposed to Nitrofen.
Zeman, F. J. ;
Heng, H. ;
Hoogenboom, E. R. ;
Mahboob, S. ;
Kavlock, R. J. ;
||California Univ., Davis. Dept. of Nutrition.;Health Effects Research Lab., Research Triangle Park, NC.
Laboratory animals ;
Congenital abnormalities ;
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The effects of maternal exposure to nitrofen or protein-energy malnutrition on the number and sizes of cells in selected organs of the fetal rat have been studied. Pregnant rats were fed either an adequate (CON) or protein-energy deficient diet (PEM) throughout gestation. Maternal nitrofen exposure resulted in reduced weight and reduced protein in all organs except the brain. The data indicate that maternal protein-energy malnutrition results in smaller organs in the fetuses with fewer cells and containing less protein and RNA. The greater reduction in protein than that expected from the decrease in numbers of cells in the liver, intestine, and brain in fetuses of malnourished dams suggest that cells were also smaller. (Copyright (c) 1986 Alan R. Liss, Inc.)