| Main Title |
DNA Adduct Formation by 7,12-Dimethylbenz(a)anthracene and its Noncarcinogenic 2-Fluoro Analogue in female Sprague-Dawley Rats. |
| Author |
Daniel, F. B. ;
Joyce, N. J. ;
|
| CORP Author |
Health Effects Research Lab., Cincinnati, OH. |
| Year Published |
1982 |
| Report Number |
EPA-600/J-83-008; EPA-R-807895; |
| Stock Number |
PB83-194548 |
| Additional Subjects |
Deoxyribonucleic acids ;
Females ;
Rats ;
Laboratory animals ;
Reprints ;
Polycyclic aromatic hydrocarbons ;
Benzanthracene/dimethyl
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB83-194548 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
The potent polycyclic aromatic hydrocarbon 7.2 dimethylbenz(a)anthracene (DMBA) bound to the DNA of numerous organs of the female outbred Sprague-Dawley rat after iv administration under a regimen known to produce a high yield of mammary adenocarcinomas. The maximum DNA binding levels observed following iv administration of 5 mg DMBA range from approximately 12 micromol hydrocarbon/mol deoxyribonucleic for the liver to approximately 5 micromol hydrocarbon/mol deoxyribonucleotide for the mammary gland, the target tissue. |
