Record Display for the EPA National Library Catalog


Main Title Glutathione Peroxidase and Glutathione Transferase Activity in Rat Lung and Liver Following Cadmium Inhalation.
Author Grose, E. C. ; Richards, J. H. ; Jaskot, R. H. ; Menache, M. G. ; Graham, J. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Durham, NC. Inhalation Toxicology Group. ;North Carolina State Univ. at Raleigh.
Year Published 1987
Report Number EPA/600/J-87/088;
Stock Number PB88-125539
Additional Subjects Toxicology ; Cadmium ; Enzyme inhibitors ; Respiration ; Exposure ; Lung ; Liver ; Laboratory animals ; Rats ; Toxicity ; Reprints ; Glutathione peroxidase ; Glutathione transferases ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB88-125539 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
A 2 hr inhalation exposure to 4.6 mg Cd/cu m decreased pulmonary total glutathione peroxidase (GSH Px) activity and non-selenium peroxidase (GSH non-Se-Px) activity but had no effect on GSH selenium peroxidase (Se-Px) activity. Seventy-two hrs after exposure there was an increase in total GSH Px and GSH Se-Px activity. Exposure to 0.44 mg Cd/cu m for 2 hr caused no effect on GSH Se-Px at either 0 or 72 hr post exposure, but total GSH Px and GSH non-Se-Px activities were decreased up to 72 hr post exposure. Exposure to 4.6 mg Cd/cu m caused an increase in hepatic GSH Se-Px activity 72 hr post exposure, but no other significant changes were observed in the liver. Changes in GSH non-Se-Px activity did not relate to changes in GSH transferase (Tr) activity. The data suggest that alterations in GSH Px activity by Cd(+2) may be due to changes in GSH non-Se-Px activity and that changes in pulmonary GSH Tr and GSH non-Se-Px activities may not be as closely linked as in the liver. (Copyright (c) 1987 Elsevier Scientific Publishers Ireland Ltd.)