Record Display for the EPA National Library Catalog

RECORD NUMBER: 16 OF 17

OLS Field Name OLS Field Data
Main Title Review of the Mutagenicity of Ethylene Oxide.
Author Dellarco, V. L. ; Generoso, W. M. ; Sega, G. A. ; Fowle, J. R. ; Jacobson-Kram, D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Oak Ridge National Lab., TN. Biology Div.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/550;
Stock Number PB92-124569
Additional Subjects Mutagens ; Ethylene oxide ; Toxicology ; Deoxyribonucleic acids ; Risk assessment ; Alkylating agents ; Mutations ; Cultured cells ; Chromosomes ; Linkage(Genetics) ; Lethal genes ; Dominant genes ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB92-124569 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 02/24/1992
Collation 21p
Abstract
Ethylene oxide has been shown to be an effective mutagen in a variety of organisms ranging from bacteria to mammalian cells. There is also an association between ethylene oxide exposure and human somatic cell cytogenetic damage. Furthermore, ethylene oxide has been shown to alkylate protein and DNA at exposure levels that have been encountered occupationally. Ethylene oxide is not only effective at producing somatic cell mutations but also at inducing genetic damage in germ cells. While it is clear that ethylene oxide is a germ cell mutagen in whole mammals, the mechanism(s) by which it produces genetic lesions in germ cells is uncertain. (Copyright (c) 1990 Wiley-Liss, Inc.)