Record Display for the EPA National Library Catalog


Main Title Ozone Concentration and Pulmonary Response Relationships for 6.6-Hour Exposures with Five Hours of Moderate Exercise to 0.08, 0.10, and 0.12 PPM.
Author Horstman, D. H. ; Folinsbee, L. J. ; Ives, P. J. ; Salaam, S. A. ; McDonnell, W. F. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Clinical Research Branch.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/487;
Stock Number PB91-191486
Additional Subjects Ozone ; Exercise ; Air pollution effects(Humans) ; Dose-response relationships ; Respiratory function tests ; Airway resistance ; Exposure ; Statistical analysis ; Signs and symptoms ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB91-191486 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
The magnitudes of pulmonary responses the authors previously observed (1) following 6.6-h exposure to 0.12 ppm ozone (O3) suggested that responses would also occur with similar exposures at lower O3 concentrations. The objective of the study was to determine the extent of pulmonary function decrements, respiratory discomfort, and increased airway reactivity to methacholine induced by exposure to O3 below 0.12 ppm. Separate 6.6-h chamber exposures to 0.00, 0.08, 0.10, and 0.12 ppm O3 included six 50-min periods of moderate exercise (VE = 39 L/min, HR = 115 bpm, and VO2 = 1.5 L/min). Each exercise period was followed by 10 min of rest. A 35-min lunch break was included midway through the exposure. Although not intended as an exact simulation, the overall duration, intensity, and metabolic requirements of the exercise performed were representative of a day of moderate to heavy work or play. Preexposure FEV, averaged 4.39 L, and essentially no change (+0.03 L) occurred with exposure to 0.00 ppm O3. Significant decreases (p<0.01) of -0.31, -0.30, and -0.54 L were observed with exposures to 0.08, 0.10, and 0.12 ppm, respectively. The study concludes that exposure to O3 at levels often found in ambient air while engaged in activity representative of a typical day of moderate to heavy work or play induced clinically meaningful pulmonary responses.