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RECORD NUMBER: 2 OF 10

Main Title Carcinogenicity and pesticides : principles, issues, and relationships. Biological issues in extrapolation. /
Author Yang, Raymond S. H. ; Huff, J. ; Germolec, D. R. ; Luster, M. I. ; Simmons, J. E.
Other Authors
Author Title of a Work
Huff, J.
Germolec, D. R.
Luster, M. I.
Simmons, Jane Ellen.
Seely, J. C.
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;PATHCO, Inc., Research Triangle Park, NC. ;Department of Agriculture, Washington, DC. ;Maryland Univ., College Park.;American Chemical Society, Washington, DC.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1989
Report Number EPA/600/D-90/038
Stock Number PB90-220799
Subjects Pesticides--Carcinogenicity--Congresses ; Carcinogenesis--Congresses ; Carcinogens, Environmental--toxicity ; Neoplasms--chemically induced ; Pesticides--toxicity ; Carcinogens, Environmental--toxicity--congresses ; Neoplasms--chemically induced--congresses ; Pesticides--toxicity--congresses
Additional Subjects Toxicology ; Pesticides ; Tables(Data) ; Extrapolation ; Reprints ; Carcinogenicity tests ; Risk assessment ; Species specificity ; Immune system
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  PB90-220799 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 25 pages : illustrations ; 28 cm.
Abstract
To assess potential risks of chemicals to humans, extrapolation of the findings in laboratory animals to possible health effects in humans is inevitable. Several important biological issues must be considered in such a process; these include extrapolation between doses, species (including strain and sex), routes of administration and exposure regimens (e.g., intermittent vs constant rate). While there is no perfect surrogate for humans in the evaluation of carcinogenic potential and other toxicities of chemicals and other agents, rodents still represent the best models. Any imperfection in such a process (i.e., hazard identification and risk assessment of any given chemical or other agent) must be taken into consideration during extrapolation.
Notes
"Developed from a symposium sponsored by the Division of Agrochemicals at the 196th National Meeting of the American Chemical Society, Los Angeles, California, September 25-30, 1988." Includes bibliographical references. "Jane Ellen Simmons, project officer." Microfiche.
Contents Notes
EPA/600/D-90/038.