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Main Title Neurotoxic effects of controlled exposure to a complex mixture of volatile organic compounds /
Author Otto, David A. ; Molhave, L. ; Hudnell, H. K. ; Goldstein, G. ; O'Neil, J.
Other Authors
Author Title of a Work
Otto, David A.,
MĀ²lhave, Lars,
Hudnell, H. Kenneth,
Goldstein, George M.,
John O'Neil,
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Aarhus Univ. (Denmark). ;Northrop Services, Inc., Research Triangle Park, NC. ;CE Environmental, Inc., Chapel Hill, NC.
Publisher Health Effects Laboratory,
Year Published 1990
Report Number EPA/600/1-90/001
Stock Number PB90-186438
OCLC Number 224814869
Subjects Neurotoxicology ; Organic compounds ; Volatile organic compounds
Additional Subjects Toxicology ; Exposure ; Eye(Anatomy) ; Nose(Anatomy) ; Pharynx ; Sensitivity ; Buildings ; Graphs(Charts) ; Tables(Data) ; Volatile organic compounds ; Biological effects ; Indoor air pollution
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA 600-1-90-001 Headquarters Library/Washington,DC 05/06/2014
NTIS  PB90-186438 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation v, 98 pages ; 28 cm.
Subjective reactions of discomfort, impaired air quality, irritation of mucosal membranes, and impaired memory have been reported in chemically sensitive subjects during exposure to volatile organic compounds (VOCs) found in new buildings. 66 normal healthy male subjects aged 18-39 were exposed for 2.75 hrs to a complex VOC mixture at O and 25 mg/cu m. Each subject completed control and exposure sessions at one week intervals in counterbalanced order. Measurements included comfort ratings of eye, nose and throat irritation, symptom questionnaire and computerized behavioral tests. Subjects found the odor of VOCs unpleasant and strong and reported that VOC exposure degraded air quality, increased headache and produced general discomfort. VOC exposure did not affect performance on any behavioral tests. Results indicate that subjective reactions to VOCs are not limited to chemically sensitive individuals since the study population is a subgroup that is probably least likely to be affected by chemical exposure.
Contract Number: EPA Contract 68-02-4179 Contract Number: EPA Contract 68-20-3800 Reproduction by U.S. Dept. of Commerce, National Technical Information Service, Springfield, VA.