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OLS Field Name OLS Field Data
Main Title Comparability of Rat and Human Visual-Evoked Potentials.
Author Hudnell, H. K. ; Boyes, W. K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/057;
Stock Number PB91-191643
Additional Subjects Visual evoked potentials ; Comparative evaluations ; Rats ; Humans ; Diazepam ; Amplitude ; Species specificity ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB91-191643 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 09/04/1991
Collation 8p
Abstract
A series of experiments was conducted to assess the comparability of physiological processes in rat and human visual systems. In the first set of experiments, transient visual evoked potentials (VEPs) were elicited by the onset of sine-wave gratings of various spatial frequencies. The spatial frequency-response profiles of the first positive and immediately succeeding negative components differed from one another, but were similar in the two species. In addition, amplitude of the negative, but not the positive, component was strongly attenuated in both species following stationary pattern adaptation. In the second set of experiments, steady-state VEPs were elicited by the onset and offset of the gratings. The spatial frequency profiles of the 1F (response amplitude at the frequency of stimulus onset-offset) and 2F response components differed from one another, but were similar in both species. The final set of experiments indicated that diazepam, a GABA agonist, reduced amplitude of 2F, but not 1F, in both species.