Record Display for the EPA National Library Catalog

RECORD NUMBER: 5 OF 20

Main Title Cytogenetic Distinction between the TK+ and TK- Chromosomes in the L5178Y TK+/- 3.7.2C Mouse-Lymphoma Cell Line.
Author Hozier, J. ; Sawyer, J. ; Clive, D. ; Moore, M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Florida Inst. of Tech., Melbourne.;Burroughs Wellcome Co., Research Triangle Park, NC.
Year Published 1982
Report Number EPA/600/J-82/462;
Stock Number PB86-202975
Additional Subjects Chromosomes ; Lymphoma ; Mice ; Mutants ; Reprints ; Cell lines ; Cytogenesis ; Mutagenesis
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NTIS  PB86-202975 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 7p
Abstract
The authors have analyzed the banded metaphase karyotypes of the L5178Y TK+/-3.72C mouse-lymphoma cell line as well as a class of slow growing (o) TK-/-mutants which show chromosome 11 rearrangements. The authors have discovered a centromeric heteromorphism in the chromosomes 11 (the known location of the thymidine kinase gene in the mouse) which, together with the types of chromosome rearrangements thus far catalogued for TK+/- TK-/- mutagenesis, allows us to propose a cytogenetic distinction between the TK-competent (TK+) and TK-deficient (TK-) chromosome.