Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Sulfur Dioxide-Induced Bronchoconstriction in Asthmatics Exposed for Short Durations under Controlled Conditions: A Selected Review.
Author Horstman, D. H. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1987
Report Number EPA/600/D-87/333;
Stock Number PB88-129218
Additional Subjects Asthma ; Sulfur dioxide ; Exposure ; Toxicology ; Respiratory diseases ; Environmental health ; Bronchoconstriction
Library Call Number Additional Info Location Last
NTIS  PB88-129218 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 31p
Prior to 1980, essentially no health related effects had been observed for short-term ( < 1 hr) exposures to sulfur dioxide (SO2) levels similar to those found in the ambient environment (= or < 1 ppm). In 1980 and 81, the results from several studies indicated that asthmatics' airways were substantially more responsive to SO2 than those of nonasthmatic individuals and that, when combined with moderate exercise, significant bronchoconstriction resulted from exposures to as low as 0.5 ppm SO2. Since then, a multitude of reports regarding short-term exposure of asthmatics to low SO2 levels have appeared in the literature. From these studies, reflex bronchoconstriction, mast cell degranulation and other, yet unidentified, mechanisms have been implicated in the induction of response. A broad range of responsiveness to SO2 exists within the asthmatic population. Precise knowledge of factors involved in this variable responsiveness is lacking; differences in nonspecific airway sensitivity and severity of disease have been suggested.