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Main Title Assessment of the carcinogenicity of dicofol (Kelthane{TM}), DDT, DDE, and DDD (TDE) {microform} /
Author Holder, James W.
CORP Author Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher Office of Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency,
Year Published 1986
Report Number EPA/600/6-86/001
Stock Number PB87-110904
Subjects Pesticides--Toxicology ; Carcinogenicity testing--United States ; Liver Neoplasms--chemically induced ; Pesticides--toxicity ; Carcinogenicity Tests
Additional Subjects Toxicity ; Hazardous materials ; Assessments ; Carcinogens ; Malignant neoplasms ; Epidemiology ; Pesticides ; Persistence ; Neoplasms ; Concentration(Composition) ; Chlorine organic compounds ; Toxic substances ; Environmental health ; Carcinogenesis ; DDT ; DDE insecticide ; DDD insecticide ; Dicofol
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
NTIS  PB87-110904 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 85 p. ; 28 cm.
The carcinogenic activity of the pesticides dicofol and associated pesticide compounds DDT, DDE, and DDD are reviewed. All of these compounds exhibit carcinogenic activity in surrogate test animals. DDT is judged on the bases of these biotests, positive mutagenicity in vivo, two-stage chemical carcinogenesis tests, and the lack of relevant epidemiological tests to be probably carcinogenic to man. Dicofol, DDT, DDE, DDD animal test data, when analyzed by the linearized multistage model for low-dose extrapolation, show similar cancer potencies: q*1 = 0.44, 0.34, 0.34, 0.25, respectively,/(mg/kg/day). Such similiarity in cancer potency values suggests that either a common carcinogenic metabolite is generated from these compounds, or each compound has intrinsic carcinogenic activity and need not be metabolized to any other compound in order to cause cancer.
Photocopy. Microfiche.