Record Display for the EPA National Library Catalog


Main Title Analysis of 2,3,7,8-TCDD Tumor Promotion Activity and Its Relationship to Cancer.
Author Holder, J. W. ; Menzel, H. M. ;
CORP Author Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. ;Hessische Landesanstalt fuer Umwelt, Wiesbaden (Germany, F.R.).
Publisher Mar 90
Year Published 1990
Report Number OHEA-C-287 ;EPA/600/D-90/006;
Stock Number PB90-187253
Additional Subjects Malignant neoplasms ; Carcinogens ; Rats ; Mice ; Exposure ; Bioassay ; Tables(Data) ; Reprints ; Tetrachlorodibenzo-p-dioxin ; Carcinogenicity tests ; Dose-response relationships
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
NTIS  PB90-187253 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has a high estimated cancer potency in animals which has been reasoned to imply that TCDD might be carcinogenic to man. The animal cancer data show that TCDD can act in a solitary manner causing tumors without the participation of other known factors. However, there exist animal cancer data indicating that TCDD can act as a tumor-promoting compound. The analysis examines which type of carcinogen and which mechanism best characterize TCDD cancer activity. It is suggested that TCDD acts by a hormonal mechanism to cause cancer in a solitary manner, at low doses, in two species, and in a number of different organs, including rare sites. These observations in toto characterize TCDD as a complete carcinogen, which by definition encompasses both initiation and promotion carcinogenic activities.