Record Display for the EPA National Library Catalog


Main Title Use of Gamma-Hexachlorocyclohexane (Lindane) to Determine the Ontogeny of Metabolism in the Developing Rat.
Author Copeland, M. F. ; Chadwick, R. W. ; Cooke, N. ; Whitehouse, D. A. ; Hill, D. M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/179;
Stock Number PB87-116679
Additional Subjects Insecticides ; Toxicology ; Bioassay ; Chlorine organic compounds ; Rats ; Laboratory animals ; Reprints ; Lindane ; Cyclohexane/hexachloro
Library Call Number Additional Info Location Last
NTIS  PB87-116679 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 18p
The compound lindane has been used as a model substrate to study the ontogeny of metabolism in the developing Fischer 344 rat. The distribution and metabolic fate of the model substrate at 2, 9, 16, and 23 days of age was investigated following subcutaneous administration of 20 mg/kg of lindane containing 0.5 micro Ci (U14C)-lindane in peanut oil. Groups of ten pups (5 male and 5 female) were sacrificed at 4 hr intervals during the 24 hr period following dosing. Adrenals, blood, brain, heart, lung, liver, and kidneys were analyzed for radioactivity. Urine samples were analyzed for radioactivity and metabolites of lindane. There was a significant age dependent increase in the metabolism of lindane in the rat. High levels of radioactivity in the lung and increased reductive dechlorination suggest that the lung may play a greater role in metabolism of lindane by young rats. Oxidative phase I reactions increased significantly while anaerobic reductive dechlorination of lindane to 4-chlorophenylmercapturic acid decreased significantly with age.