Main Title |
Time-Course and Sensitivity of Muconic Acid as a Biomarker for Human Environmental Exposure to Benzene. |
Author |
Buckley, T. J. ;
Lindstrom, A. B. ;
Highsmith, V. R. ;
Bechtold, W. E. ;
Sheldon, L. S. ;
|
CORP Author |
Environmental Protection Agency, Research Triangle Park, NC. Atmospheric Research and Exposure Assessment Lab. ;Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM. Inhalation Toxicology Research Inst. ;Research Triangle Inst., Research Triangle Park, NC. |
Publisher |
1992 |
Year Published |
1992 |
Report Number |
EPA/600/A-92/248; |
Stock Number |
PB93-121044 |
Additional Subjects |
Benzene ;
Biological markers ;
Toxicology ;
Environmental exposure ;
Chemical water pollutants ;
Humans ;
Dose-response relationships ;
Urine ;
Muconic acids
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB93-121044 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
8p |
Abstract |
Preliminary results are presented that show the effect of increased benzene exposure on the urinary elimination of trans,trans-muconic acid (MA) for an adult male. The results were generated from a controlled exposure experiment whereby an individual was exposed to benzene during a shower with gasoline-contaminated ground water. Based on measured air and water concentrations, it is estimated that the 25 minute shower and drying-off exposure period resulted in an inhalation and dermal absorbed dose of 122 micrograms and 19 micrograms, respectively, yielding an average dose rate of 334 micrograms/h during the shower period. The measured background dose rate of 1.2 micrograms/h was exceeded by a factor of 278 during the shower exposure. The average urinary MA elimination rate increased from 3.7 micrograms/h during the 30 h period before the exposure to 17.9 micrograms/h during the 22 h period after the exposure. The post-exposure profile of muconic acid elimination (micrograms/h) was characterized by two minor peaks (47 and 35 micrograms/h) occurring within 3 h and a major peak (61 micrograms/h) at approximately 11 h. |