Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Supplementary guidance for conducting health risk assessment of chemical mixtures.
Author H. CHOUDHURY ; R. Hertzberg ; G. Rice ; J. COGLIANO ; D. Mukerjee
Other Authors
Author Title of a Work
Choudhury, Harlal.
L. Teuschler
CORP Author Environmental Protection Agency, Washington, DC. Risk Assessment Forum.
Publisher U.S. Environmental Protection Agency, Office of Research and Development,
Year Published 2000
Report Number EPA/630/R-00/002
Stock Number PB2009-102648
OCLC Number 47780128
Subjects Environmental toxicology. ; Environmental health. ; Health risk assessment.
Additional Subjects Chemical mixtures ; Hazardous materials ; Health risks ; Risk assessments ; Method selection procedures ; Guidelines ; Data quality assessment ; Exposure assessments ; Mixture components ; Whole mixtures ; Environmental transformation ; Response addition ; Pharmacokinetics ; Chemical mixture risk assessments ; Slope factors ; Comparative potency ; Relative potency factors ; Hazard indexes
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EHAD  EPA/630-R-00-002 Region 1 Library/Boston,MA 08/24/2001
EHBD  EPA/630/R-00/002 CEMM/ACESD Library/Narragansett,RI 04/06/2007
EJBD ARCHIVE EPA 630/R-00/002 Headquarters Library/Washington,DC 03/03/2009
EJED  EPA 630/R-00/002 OCSPP Chemical Library/Washington,DC 01/02/2004
EKBD  EPA-630/R-00-002 Research Triangle Park Library/RTP, NC 10/05/2001
EKCD  EPA/630/R-00/002 CEMM/GEMMD Library/Gulf Breeze,FL 11/27/2018
ELBD  EPA 630-R-00-002 AWBERC Library/Cincinnati,OH 09/07/2001
EMBD  EPA/630/R-00/002 2 Copies NRMRL/GWERD Library/Ada,OK 05/17/2002
ERAD  EPA 630/R-00/002 2 copies Region 9 Library/San Francisco,CA 03/25/2016
ESAD  EPA 630-R-00-002 Region 10 Library/Seattle,WA 09/21/2001
NTIS  PB2009-102648 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 04/28/2010
Collation 1 volume (various pagings) : illustrations ; 28 cm.
This supplementary guidance document is organized according to the type of data available to the risk assessor, ranging from data rich to data poor situations. This organization reflects the approaches to chemical mixture risk assessment recommended in the 1986 Guidelines for the Health Risk Assessment of Chemical Mixtures (Appendix A). This document describes more detailed procedures for chemical mixture assessment using data on the mixture of concern, data on a toxicologically similar mixture, and data on the mixture component chemicals. The state-of-the-science varies dramatically for these three approaches. It is recommended that the risk assessor implement several of the approaches that are practical to apply and evaluate the range of health risk estimates that are produced. This document suggests that the selection of a chemical mixture risk assessment method follows the outline in the flow chart shown in Figure 2-1, which begins with an assessment of data quality and then leads the risk assessor to selection of a method through evaluation of the available data. The major concerns for the user are whether the available data are on components or whole mixtures, whether the data are composed of either similar components or similar mixtures that can be thought of as acting by similar toxicologic processes, and whether the data may be grouped by emissions source, chemical structure, or biologic activity.
"EPA 630/R-00-002." "U.S. Environmental Protection Agency." "August 2000." Includes bibliographical references.