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Main Title Inflammation in the Pathogenesis of Chronic Diseases The COX-2 Controversy / [electronic resource] :
Author Harris, Randall E.
Other Authors
Author Title of a Work
Bittman, R.
Dasgupta, D.
Engelhardt, H.
Flohe, L.
Herrmann, H.
Holzenburg, A.
Nasheuer, H-P.
Rottem, S.
Wyss, M.
Zwickl, P.
Publisher Springer Netherlands,
Year Published 2007
Call Number RC261-271
ISBN 9781402056888
Subjects Medicine ; Oncology ; Immunology ; Neurosciences ; Cardiology ; Neurology ; Pathology
Internet Access
Description Access URL
Collation XIII, 323 p. online resource.
Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes
Historical Perspectives -- Anti-Inflammatory Drugs in the 21st Century -- Inflammatory Mechanisms of Pathogenesis -- Nitric Oxide Synthase and Cyclooxygenase Interactions in Cartilage and Meniscus -- Obesity, Inflammation, and Vascular Disease -- Cyclooxygenase-2 (COX-2) and the Inflammogenesis of Cancer -- Role of COX-2 in Inflammatory and Degenerative Brain Diseases -- Inflammation and Cardiovascular Disease: The Coxib Controversy -- Cardiovascular Effects of the Selective Cyclooxygenase-2 Inhibitors -- COX-2 Inhibitors And Cardiovascular Risk -- A Biological Rationale for the Cardiotoxic Effects of Rofecoxib -- Cox-2 Blockade in Cancer Prevention and Therapy -- Cancer Chemoprevention by Cyclooxygenase 2 (COX-2) Blockade -- Strategies for Colon Cancer Prevention -- Inflammation and Neurodegenerative Disease -- NSAIDs for the Chemoprevention of Alzheimer's Disease -- Inflammation in parkinson's disease -- Nutrition, Inflammation and Chronic Disease -- Essential Polyunsaturated Fatty Acids, Inflammation, Atherosclerosis and Cardiovascular Diseases -- Nutritional Intervention in Brain Aging. In "Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy", a panel of leading experts chronicles the evidence supporting the roleofinflammationinthepathogenesisofmajorchronicdiseasesanddiscusses the current controversy regarding beneficial versus adverse effects of selective cyclooxygenase-2(COX-2)inhibitors.Expertsinmultipledisciplinesofmedical research provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine. The book is broadly divided into fivesections. Webeginwithhistoricalperspectivesonthediscoveryanddev- opment of aspirin, ibuprofen, and compounds that selectively inhibit COX-2, including discussion of risk versus benefit and the potential for development of new compounds with better efficacy and safety in the 21st century. This is followed by a section illuminating the role of inflammatory mechanisms in the pathogenesisofarthritis,cardiovasculardisease,cancer,neurodegenerativedisease, diabetes mellitus, obesity, and other life-threatening and debilitating conditions. Specific chapters then explore the "COX-2 controversy" regarding the potential forpositiveversusnegativeimpactofselectiveCOX-2inhibitorsonthecard- vasculature.Recentfindingssuggestthatcardiovascularriskassociatedwithsome COX-2 inhibitors may not be due to a class effect involving COX-2 inhibition, butratherdependsuponthemolecularstructureofspecificcompoundsthathave independenteffectsunrelatedtoCOX-2andprostaglandinbiosynthesis.Important findingsaredocumentedincancerresearchshowingthatselectiveCOX-2inhibitors havepowerfulantineoplasticeffectsagainstmajorformsofcancer.Aspecialsection exploresthecurrentevidencesupportingtheroleofCOX-2andinflammationinthe development of Alzheimer's disease and other neurodegenerative conditions and thepotentialbenefitofcompoundsthatmodulateCOX-2andotherinflammatory cytokines.Thefinalsectionaddressesnutritionalmodulationofinflammationinthe pathogenesisofchronicdiseaseandthechemopreventivevalueofanti-inflammatory nutraceuticalagents.