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Main Title Alterations in Rat Flash and Pattern Reversal Evoked Potentials after Acute or Repeated Administration of Carbon Disulfide (CS2).
Author Herr, D. W. ; Boyes, W. K. ; Dyer, R. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/186;
Stock Number PB92-188929
Additional Subjects Visual evoked potential ; Carbon disulfide ; Patterns ; Toxicology ; Drug administration schedule ; Dose-response relationships ; Body temperature ; Reaction time ; Flashing ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB92-188929 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 17p
Because solvents may selectively alter portions of visual evoked potentials, the authors examined the effects of carbon disulfide (CS2) on flash (FEPs) and pattern reversal (PREPs) evoked potentials. Long-Evans rats were administered (ip) carbon disulfide (CS2) either acutely or for 30 days. FEPs or PREPs were recorded prior to and 1, 2, 4, 8, or 24 hr after a single dose of CS2 (0, 100, 200, 400, or 500 mg/kg). Flash evoked potentials were also recorded 1, 2, 6, and 24 hr after the last of 30 doses of 200 mg CS2/kg/day. Acute exposure to CS2 consistently decreased the amplitude of FEP peak N160 at 1 hr, depressed peak N30 amplitude over 2-4 hr, and increased the latency of peaks P21, N30, P46, N56, and N160 for up to 4 hr after treatment. Carbon disulfide decreased the amplitude of PREP peaks P65, N83, P88, and N122 4 hr after treatment. Colonic temperature was depressed up to 8 hr after treatment. Administration of 200 mg CS2/kg/day decreased the amplitude of FEP peak N30 and increased the latencies of peaks P21, N30, P46, N56, and N160 up to 24 hr after the last dose. The differential effects of CS2 on portions of FEPs indicates that FEP peaks can be independently modulated. (Copyright (c) 1992 Society of Toxicology.)