Record Display for the EPA National Library Catalog
RECORD NUMBER: 2 OF 12Main Title | Airway Sensitivity of Asthmatics to Sulfur Dioxide. | |||||||||||
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Author | Horstman, D. ; Roger, L. J. ; Kehrl, H. ; Hazucha, M. ; | |||||||||||
CORP Author | Health Effects Research Lab., Research Triangle Park, NC. Clinical Research Branch. ;Environmental Monitoring and Services, Inc., Chapel Hill, NC. ;North Carolina Univ. at Chapel Hill. | |||||||||||
Year Published | 1986 | |||||||||||
Report Number | EPA/600/J-86/282; | |||||||||||
Stock Number | PB87-175600 | |||||||||||
Additional Subjects | Sulfur dioxide ; Asthma ; Respiratory system ; Exposure ; Sensitivity ; Exercise(Physiology) ; Air pollution ; Methacholines ; Reprints ; Air pollution effects(Humans) ; Bronchial provocation tests ; Sraw(Specific Airway Resistance) | |||||||||||
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Collation | 12p | |||||||||||
Abstract | Airways' sensitivity to SO2, (PC(SO2)), was defined as the concentration of SO2 which provoked a 100% increase in specific airways' resistance (SRaw). PC(SO2) was determined for 2. asthmatics performing moderate exercise while exposed to several concentrations of SO2 up to 2.0 ppm. Substantial variability in sensitivity was observed: for 20% of the subjects, PC(SO2) was greater than 1.95 ppm SO2, while for the remaining 80%, it ranged between 0.28 and 1.38 ppm SO2. The median PC(SO2) was 0.75 ppm SO2. PC(SO2) and nonspecific airways' sensitivity to methacholine were not related. (Copyright (c) Toxicology and Industrial Health, Vol. 2, No. 3, 1986.) |